A FEW OF OVER 150  REFERENCES ON PTH TOXICITY IN UREMIA

1. Massry SG: Parathyroid hormone: a uremic toxin. Adv Exp Med Biol 223:1-26, 1991 

2. Brancaccio D, Galmozzi C, Pizzocaro G: [Parathormone as a uremic toxin. Physiopathological bases and general therapeutic guidelines]. Minerva Med  76:377-382, 1985 

3. Massry SG: Neurotoxicity of parathyroid hormone in uremia. Kidney Int [Suppl]  17:S5-11, 1985 

4. Akmal M, Massry SG: Role of parathyroid hormone in the decreased motor nerve conduction velocity of chronic renal failure. Proc. Soc. Exp. Biol. Med. 195:202-207, 1990

5. Baczynski R, Massry SG, Magott M, El-Belbessi S, Kohan R, Brautbar N: Effect of parathyroid hormone on energy metabolism of skeletal muscle. Kidney Int  28:722-727, 1985 

6. Perna AF, Fadda GZ, Zhou XJ, Massry SG: Mechanisms of impaired insulin secretion after chronic excess of parathyroid hormone. Am. J. Physiol. 259:F210-F216, 1990.

7. Akmal M, Kasim S, Soliman A, Massry S: Excesss parathyroid hormone adversely affects lipid metabolism in chronic renal failure. Kidney Int.  37:854-858, 1990

8. Massry SG: Parathyroid hormone and the heart. Adv Exp Med Biol 151:607-618, 1982 

9. El-Belbessi S, Brautbar N, Anderson K, Campese VM, Massry SG: Effect of chronic renal failure on heart. Role of secondary hyperparathyroidism. Am J Nephrol 6:369-375, 1986

10. Massry SG: Parathyroid hormone and uremic myocardiopathy. Contrib Nephrol  41:231-239, 1984 

11. Bogin E, Earon Y, Blum M: Effect of parathyroid hormone and uremia on erythrocyte deformability. Clin Chim Acta  161:293-299, 1986 

12. Esposito R, Romano-Carratelli C, Lanzetti N, Hohenegger M, Pluvio M, Capodicasa G, Nuzzo I, Giordano C: Toxicity in uremia. 2. Correlation between PTH levels and impaired aspecific immunity. Int J Artif Organs  11:159-160, 1988 

13. Klinger M, Alexiewicz J, Linker-Israeli M, Pitts T. Gaciong Z: Effect of parathyroid hormone on human T-cell activation Kidney Int 37:1543-1551, 1990

14. Frohling PT, Kokot F, Cernacek P, Vetter K, Kuska J, Spustova V, Kaschube I, Dzurik R: Relation between middle molecules and parathyroid hormone in patients with chronic renal failure. Miner Electrolyte Metab  7:48-53, 1982 

15. Molzahn AE: Parathyroid hormone as a uremic toxin. J Nephrol Nurs  1:13-16, 1984 

16. Healy MD, Malluche HH, Goldstein DA, Singer FR, Massry SG: Effects of long-term therapy with calcitriol in patients with moderate renal failure. Arch Intern Med 140:1030-1033, 1980. 
(This is just to indicate that in uremic humans calcitriol has been in use well over 20 years.)